Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2366
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcc2
Name: ATP binding cassette subfamily C member 2
Acc ID: CHEBI:45863
Term: paclitaxel
Definition: A tetracyclic diterpenoid isolated originally from the bark of the Pacific yew tree, Taxus brevifolia. It is a mitotic inhibitor used in cancer chemotherapy. Note that the use of the former generic name 'taxol' is now limited, as Taxol is a registered trade mark.
Chemical ID: MESH:D017239
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcc2affects expressionISOABCC2 (Homo sapiens)6480464CTDPaclitaxel affects the expression of ABCC2 mRNAPMID:20737486
Abcc2affects response to substanceISOABCC2 (Homo sapiens)6480464CTDABCC2 protein affects the susceptibility to PaclitaxelPMID:15645438
Abcc2affects transportISOABCC2 (Homo sapiens)6480464CTDABCC2 protein affects the transport of PaclitaxelPMID:15849751
Abcc2decreases response to substanceISOABCC2 (Homo sapiens)6480464CTDABCC2 protein results in decreased susceptibility to PaclitaxelPMID:15849751
Abcc2increases exportISOABCC2 (Homo sapiens)6480464CTDABCC2 protein results in increased export of PaclitaxelPMID:19952419
Abcc2increases expressionISOAbcc2 (Mus musculus)6480464CTDPaclitaxel results in increased expression of ABCC2 mRNA; Paclitaxel results in increased expression of ABCC2 proteinPMID:28242239
Abcc2multiple interactionsISOABCC2 (Homo sapiens)6480464CTDmontelukast inhibits the reaction [ABCC2 protein results in increased export of Paclitaxel]; Probenecid promotes the reaction [ABCC2 protein affects the transport of Paclitaxel]; Probenecid promotes the reaction [ABCC2 protein results in decreased susceptibility to Paclitaxel]; verlukast inhibits the reaction [ABCC2 protein results in increased export of Paclitaxel]PMID:15849751 PMID:19952419
Go Back to source page   Continue to Ontology report