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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2366
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcc2
Name: ATP binding cassette subfamily C member 2
Acc ID: CHEBI:16978
Term: leukotriene C4
Definition: A leukotriene that is (5S,7E,9E,11Z,14Z)-5-hydroxyicosa-7,9,11,14-tetraenoic acid in which a glutathionyl group is attached at position 6 via a sulfide linkage.
Chemical ID: MESH:D017997
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcc2affects transportEXP 6480464CTDABCC2 protein affects the transport of Leukotriene C4PMID:15507541 PMID:15904671 PMID:9430713
Abcc2increases transportEXP 6480464CTDABCC2 protein modified form results in increased transport of Leukotriene C4PMID:15904671
Abcc2affects transportISOABCC2 (Homo sapiens)6480464CTDABCC2 protein affects the transport of Leukotriene C4PMID:11500505 PMID:12388192 PMID:12395335
Abcc2multiple interactionsISOABCC2 (Homo sapiens)6480464CTDverlukast inhibits the reaction [ABCC2 protein results in increased transport of Leukotriene C4]PMID:27676153
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