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GENE - TERM ANNOTATION REPORT

RGD ID: 2364
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cltc
Name: clathrin heavy chain
Acc ID: GO:0006898
Term: receptor-mediated endocytosis
Definition: An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles.
Definition Source(s): GOC:mah, ISBN:0716731363
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cltcinvolved_inISOCLTC (Homo sapiens)1624291RGD PMID:15858577

PMID:15858577
Cltcinvolved_inIBAFB:FBgn0000319 or PANTHER:PTN000033442 or Cltc (Rattus norvegicus) or TAIR:locus:2074733 or UniProtKB:P53675 or UniProtKB:Q00610 or WB:WBGene00011867 or dictyBase:DDB_G02772211600115GO_CentralGO_REF:0000033

GO_REF:0000033
Cltcinvolved_inIEAPANTHER:PTHR10292:SF71600115TreeGrafterGO_REF:0000118

GO_REF:0000118
Cltcinvolved_inIMP 8553642UniProtPMID:15858577

 
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