GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Chrna3 | multiple interactions | EXP | | 2303194 | RGD | Nicotine affects binding [Epibatidine binds to Chrna3 protein] | | Chrna3 | multiple interactions | EXP | | 2303195 | RGD | nicotine affects binding [Epibatidine binds to Chrna3 protein] | | Chrna3 | increases activity | EXP | | 6480464 | CTD | Nicotine results in increased activity of CHRNA3 protein | PMID:19483072 | Chrna3 | multiple interactions | EXP | | 6480464 | CTD | Cocaine inhibits the reaction [Nicotine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Nicotine analog binds to and results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]; Nicotine binds to and results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]; Nicotine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]; Nicotine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein] | PMID:10336510 PMID:11600638 PMID:15615518 | Chrna3 | affects response to substance | ISO | Chrna3 (Mus musculus) | 6480464 | CTD | CHRNA3 protein affects the susceptibility to Nicotine | PMID:15275829 | Chrna3 | decreases expression | ISO | CHRNA3 (Homo sapiens) | 6480464 | CTD | Nicotine results in decreased expression of CHRNA3 mRNA | PMID:12628473 | Chrna3 | increases expression | ISO | Chrna3 (Mus musculus) | 6480464 | CTD | Nicotine results in increased expression of CHRNA3 mRNA | PMID:17135361 PMID:29293602 | Chrna3 | multiple interactions | ISO | CHRNA3 (Homo sapiens) | 6480464 | CTD | CHRNA3 protein affects the reaction [Nicotine results in increased expression of CHRNA5 mRNA]; CHRNA3 protein affects the reaction [Nicotine results in increased expression of CHRNA5 protein]; CHRNA3 protein affects the reaction [Nicotine results in increased expression of CHRNA7 mRNA]; CHRNA3 protein affects the reaction [Nicotine results in increased expression of CHRNA7 protein]; Nicotine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]; Nicotine results in increased activity of [CHRNB4 protein binds to CHRNA3 protein] | PMID:18450646 PMID:34628512 PMID:9454827 | | ||||||||||||||||||||||
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