Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2332
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cftr
Name: CF transmembrane conductance regulator
Acc ID: CHEBI:17026
Term: progesterone
Definition: A C21-steroid hormone in which a pregnane skeleton carries oxo substituents at positions 3 and 20 and is unsaturated at C(4)-C(5). As a hormone, it is involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species.
Chemical ID: MESH:D011374
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cftrmultiple interactionsEXP 6480464CTD[Genistein co-treated with estradiol-17-benzoate co-treated with Progesterone] results in increased expression of CFTR mRNA; [Genistein co-treated with estradiol-17-benzoate co-treated with Progesterone] results in increased expression of CFTR proteinPMID:26529183
Cftrdecreases expressionISOCFTR (Homo sapiens)6480464CTDProgesterone results in decreased expression of CFTR mRNA; Progesterone results in decreased expression of CFTR proteinPMID:15471937
Cftrmultiple interactionsISOCFTR (Homo sapiens)6480464CTD[Progesterone co-treated with Estradiol] results in decreased expression of CFTR mRNAPMID:17404688
Go Back to source page   Continue to Ontology report