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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2327
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cebpb
Name: CCAAT/enhancer binding protein beta
Acc ID: CHEBI:6809
Term: methamphetamine
Definition: A member of the class of amphetamines in which the amino group of (S)-amphetamine carries a methyl substituent.
Chemical ID: MESH:D008694
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cebpbincreases expressionEXP 6480464CTDMethamphetamine results in increased expression of CEBPB mRNA; Methamphetamine results in increased expression of CEBPB proteinPMID:19564919 PMID:31059759
Cebpbmultiple interactionsEXP 6480464CTD[Methamphetamine co-treated with SCH 23390] results in increased expression of CEBPB mRNA; CEBPB protein affects the reaction [Methamphetamine results in decreased expression of BCL2 protein]; CEBPB protein affects the reaction [Methamphetamine results in decreased expression of PRKN protein]; CEBPB protein affects the reaction [Methamphetamine results in decreased phosphorylation of MTOR protein]; CEBPB protein affects the reaction [Methamphetamine results in increased cleavage of CASP3 protein]; CEBPB protein affects the reaction [Methamphetamine results in increased cleavage of PARP1 protein]; CEBPB protein affects the reaction [Methamphetamine results in increased expression of BAX protein]; CEBPB protein affects the reaction [Methamphetamine results in increased expression of BECN1 protein]; CEBPB protein affects the reaction [Methamphetamine results in increased expression of DDIT4 protein]; CEBPB protein affects the reaction [Methamphetamine results in increased expression of SNCA protein]; CEBPB protein affects the reaction [Methamphetamine results in increased expression of TRIB3 protein]; CEBPB protein affects the reaction [Methamphetamine results in increased phosphorylation of TSC2 protein]PMID:19564919 PMID:31059759
Cebpbmultiple interactionsISOCEBPB (Homo sapiens)6480464CTDCEBPB protein affects the reaction [Methamphetamine results in decreased expression of PRKN protein]; CEBPB protein affects the reaction [Methamphetamine results in increased expression of TRIB3 protein]PMID:31059759
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