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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2327
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cebpb
Name: CCAAT/enhancer binding protein beta
Acc ID: CHEBI:17823
Term: calcitriol
Definition: A hydroxycalciol that is calcidiol in which the pro-S hydrogen of calcidiol is replaced by a hydroxy group. It is the active form of vitamin D3, produced fom calciol via hydoxylation in the liver to form calcidiol, which is subsequently oxidised in the kidney to give calcitriol.
Chemical ID: MESH:D002117
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cebpbdecreases expressionISOCebpb (Mus musculus)6480464CTDCalcitriol results in decreased expression of CEBPB mRNA; Calcitriol results in decreased expression of CEBPB proteinPMID:16467308
Cebpbincreases expressionISOCEBPB (Homo sapiens)6480464CTDCalcitriol results in increased expression of CEBPB mRNA; Calcitriol results in increased expression of CEBPB proteinPMID:14729647 PMID:16002434 PMID:19748465
Cebpbmultiple interactionsISOCebpb (Mus musculus)6480464CTD[Calcitriol results in increased expression of RUNX1T1 protein] which results in decreased activity of CEBPB proteinPMID:16467308
Cebpbmultiple interactionsISOCEBPB (Homo sapiens)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Calcitriol results in increased expression of CEBPB mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Calcitriol results in increased expression of CEBPB protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole promotes the reaction [Calcitriol results in increased expression of CEBPB mRNA]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole promotes the reaction [Calcitriol results in increased expression of CEBPB protein]; [CAMP results in increased activity of CEBPB] affects the reaction [Calcitriol results in increased expression of ATG5 mRNA]; [CAMP results in increased activity of CEBPB] affects the reaction [Calcitriol results in increased expression of BECN1 mRNA]; Calcitriol results in increased expression of and affects the localization of CEBPB protein; CAMP mutant form inhibits the reaction [Calcitriol results in increased expression of CEBPB mRNA]; CEBPB mutant form inhibits the reaction [Calcitriol results in increased expression of ATG5 mRNA]; CEBPB mutant form inhibits the reaction [Calcitriol results in increased expression of BECN1 mRNA]; pyrazolanthrone inhibits the reaction [Calcitriol results in increased expression of CEBPB mRNA]; pyrazolanthrone inhibits the reaction [Calcitriol results in increased expression of CEBPB protein]; ZK159222 inhibits the reaction [Calcitriol results in increased expression of CEBPB protein]PMID:14729647 PMID:19748465 PMID:22751936
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