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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2326
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cebpa
Name: CCAAT/enhancer binding protein alpha
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cebpaincreases activityISOCEBPA (Homo sapiens)6480464CTDTretinoin results in increased activity of CEBPA proteinPMID:16226872
Cebpamultiple interactionsISOCebpa (Mus musculus)6480464CTDTretinoin inhibits the reaction [CEBPA protein binds to RETN promoter]PMID:15047602
Cebpamultiple interactionsISOCEBPA (Homo sapiens)6480464CTDPTK2 protein inhibits the reaction [Tretinoin promotes the reaction [CEBPA protein binds to RB1 protein]]; PTK2 protein inhibits the reaction [Tretinoin results in increased activity of CEBPA protein]; Tretinoin inhibits the reaction [CEBPA protein binds to ALB promoter]; Tretinoin promotes the reaction [CEBPA protein binds to MIR223 promoter]; Tretinoin promotes the reaction [CEBPA protein binds to RB1 protein]; Tretinoin promotes the reaction [CEBPA protein results in increased expression of MIR223 mRNA]PMID:16226872 PMID:16325577 PMID:16608438
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