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GENE - TERM ANNOTATION REPORT

RGD ID: 2324431
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Prdm16
Name: PR/SET domain 16
Acc ID: DOID:384
Term: Wolff-Parkinson-White syndrome
Definition: A form of ventricular pre-excitation characterized by a short PR interval and a long QRS interval with a delta wave. In this syndrome, atrial impulses are abnormally conducted to the HEART VENTRICLES via an ACCESSORY CONDUCTING PATHWAY that is located between the wall of the right or left atria and the ventricles, also known as a BUNDLE OF KENT. The inherited form can be caused by mutation of PRKAG2 gene encoding a gamma-2 regulatory subunit of AMP-activated protein kinase.
Definition Source(s): MESH:D014927
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Prdm16 ISOPRDM16 (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Wolff-Parkinson-White patternPMID:25741868 PMID:28492532 PMID:32233023
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