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GENE - TERM ANNOTATION REPORT

RGD ID: 2321145
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fbxw7
Name: F-box and WD repeat domain containing 7
Acc ID: GO:0019005
Term: SCF ubiquitin ligase complex
Definition: A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).
Definition Source(s): PMID:15571813, PMID:15688063
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fbxw7part_ofISOFBXW7 (Homo sapiens)1624291RGD PMID:12628165 PMID:15103331 PMID:17434132

PMID:12628165 PMID:15103331 PMID:17434132
Fbxw7part_ofISOFBXW7 (Homo sapiens) and UniProtKB:Q969H0-11624291RGD PMID:28007894

PMID:28007894
Fbxw7part_ofISSUniProtKB:Q9JLV61600115UniProtGO_REF:0000024

GO_REF:0000024
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