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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2319357
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nfatc1
Name: nuclear factor of activated T-cells 1
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfatc1affects localizationISONfatc1 (Mus musculus)6480464CTDLipopolysaccharides affects the localization of NFATC1 proteinPMID:27246103
Nfatc1decreases expressionISONfatc1 (Mus musculus)6480464CTDLipopolysaccharides results in decreased expression of NFATC1 mRNAPMID:22185406
Nfatc1increases expressionISONfatc1 (Mus musculus)6480464CTDLipopolysaccharides results in increased expression of NFATC1 mRNA; Lipopolysaccharides results in increased expression of NFATC1 proteinPMID:27246103 PMID:30048646
Nfatc1multiple interactionsISONFATC1 (Homo sapiens)6480464CTDEIF2AK2 protein affects the reaction [Lipopolysaccharides promotes the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]]; GW 506033X inhibits the reaction [Lipopolysaccharides promotes the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]]; Lipopolysaccharides promotes the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]PMID:27718290
Nfatc1multiple interactionsISONfatc1 (Mus musculus)6480464CTD1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [Lipopolysaccharides affects the localization of NFATC1 protein]; 9-phenanthrol inhibits the reaction [Lipopolysaccharides affects the localization of NFATC1 protein]; ABCC8 protein affects the reaction [Lipopolysaccharides results in increased expression of NFATC1 protein]; Glyburide inhibits the reaction [Lipopolysaccharides affects the localization of NFATC1 protein]; Glyburide inhibits the reaction [Lipopolysaccharides promotes the reaction [NFATC1 protein binds to NOS2 promoter]]; Lipopolysaccharides promotes the reaction [NFATC1 protein binds to NOS2 promoter]; Thymol inhibits the reaction [Lipopolysaccharides results in increased expression of NFATC1 mRNA]; Thymol inhibits the reaction [Lipopolysaccharides results in increased expression of NFATC1 protein]; TRPM4 protein affects the reaction [Lipopolysaccharides results in increased expression of NFATC1 protein]PMID:27246103 PMID:30048646
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