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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2294
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccne1
Name: cyclin E1
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccne1affects expressionISOCCNE1 (Homo sapiens)6480464CTDQuercetin affects the expression of CCNE1 mRNAPMID:32530119
Ccne1decreases expressionISOCCNE1 (Homo sapiens)6480464CTDQuercetin results in decreased expression of CCNE1 proteinPMID:22431435 PMID:25293876
Ccne1increases expressionISOCCNE1 (Homo sapiens)6480464CTDQuercetin results in increased expression of CCNE1 mRNAPMID:21632981
Ccne1multiple interactionsISOCCNE1 (Homo sapiens)6480464CTD[Cisplatin co-treated with Quercetin] results in increased expression of CCNE1 mRNA; Quercetin inhibits the reaction [TNF protein results in increased expression of CCNE1 protein]; Quercetin promotes the reaction [CDKN1A protein binds to CCNE1 protein]; Tamoxifen affects the reaction [Quercetin affects the expression of CCNE1 mRNA]PMID:12589822 PMID:12934110 PMID:27514524 PMID:32530119
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