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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2286
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cbr1
Name: carbonyl reductase 1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cbr1decreases methylationISOCBR1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased methylation of CBR1 exonPMID:27901495
Cbr1increases expressionISOCBR1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of CBR1 mRNA; Benzo(a)pyrene results in increased expression of CBR1 proteinPMID:22531821
Cbr1increases expressionISOCbr1 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of CBR1 mRNAPMID:19770486 PMID:25908611 PMID:32417428
Cbr1multiple interactionsISOCbr1 (Mus musculus)6480464CTD[lipopolysaccharide, E coli O55-B5 co-treated with Benzo(a)pyrene] affects the expression of CBR1 mRNAPMID:28987381
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