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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2279
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cat
Name: catalase
Acc ID: CHEBI:6682
Term: mangiferin
Definition: A C-glycosyl compound consisting of 1,3,6,7-tetrahydroxyxanthen-9-one having a beta-D-glucosyl residue at the 6-position.
Chemical ID: MESH:C013592
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Catmultiple interactionsEXP 6480464CTDmangiferin inhibits the reaction [Cyclophosphamide results in decreased activity of CAT protein]; mangiferin inhibits the reaction [Excitatory Amino Acid Agonists results in decreased activity of CAT protein]; mangiferin inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]; mangiferin inhibits the reaction [Streptozocin results in decreased activity of CAT protein]PMID:16076520 PMID:16584858 PMID:16697266 PMID:19201465 PMID:29223569
Catincreases activityISOCAT (Homo sapiens)6480464CTDmangiferin results in increased activity of CAT proteinPMID:15161907
Catmultiple interactionsISOCAT (Homo sapiens)6480464CTDmangiferin inhibits the reaction [Mercuric Chloride results in decreased expression of CAT protein]PMID:20629087
Catmultiple interactionsISOCat (Mus musculus)6480464CTDmangiferin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CAT mRNA]; mangiferin inhibits the reaction [Benzo(a)pyrene results in decreased activity of CAT protein]; mangiferin inhibits the reaction [Dextran Sulfate results in decreased activity of CAT protein]; mangiferin inhibits the reaction [lead nitrate results in decreased activity of CAT protein]PMID:17433543 PMID:18816296 PMID:23451106 PMID:27125760
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