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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2279
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cat
Name: catalase
Acc ID: CHEBI:22977
Term: cadmium atom
Definition: A zinc group element atom that has formula Cd.
Chemical ID: MESH:D002104
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cataffects activityEXP 6480464CTDCadmium affects the activity of CAT proteinPMID:16865233 PMID:26051590
Catdecreases activityEXP 6480464CTDCadmium results in decreased activity of CAT proteinPMID:11750084 PMID:16095692 PMID:17698948 PMID:19409769 PMID:21129391 PMID:22008531 PMID:22127830 PMID:23543441 PMID:32347499 PMID:37342552 PMID:37949422
Catdecreases expressionEXP 6480464CTDCadmium results in decreased expression of CAT; Cadmium results in decreased expression of CAT proteinPMID:17125799 PMID:19615871 PMID:22013727
Catdecreases response to substanceEXP 6480464CTDCAT results in decreased susceptibility to CadmiumPMID:14977363
Catincreases activityEXP 6480464CTDCadmium results in increased activity of CAT proteinPMID:14535831 PMID:19778222 PMID:22995158
Catincreases expressionEXP 6480464CTDCadmium results in increased expression of CAT mRNAPMID:23916567
Catmultiple interactionsEXP 6480464CTD[[nickel chloride results in increased abundance of Nickel] co-treated with [Cadmium Chloride results in increased abundance of Cadmium]] results in decreased activity of CAT protein; [Arsenic co-treated with Cadmium co-treated with Lead co-treated with Mercury co-treated with Chromium co-treated with Nickel co-treated with Manganese co-treated with Iron] results in decreased activity of CAT protein; [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased activity of CAT protein; [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of CAT protein; [Cadmium co-treated with Plant Preparations] results in increased activity of CAT protein; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased activity of CAT protein]; Ascorbic Acid inhibits the reaction [Cadmium results in decreased activity of CAT protein]; bergenin inhibits the reaction [Cadmium results in decreased activity of CAT protein]; brusatol inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of CAT protein]; Cadmium results in increased activity of and results in increased expression of CAT protein; Chlorogenic Acid inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased activity of CAT protein]; dendropanoxide inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased activity of CAT protein]; diallyl tetrasulfide inhibits the reaction [Cadmium results in decreased activity of CAT protein]; diallyl tetrasulfide inhibits the reaction [Cadmium results in decreased expression of CAT]; Fatty Acids, Omega-3 inhibits the reaction [[[nickel chloride results in increased abundance of Nickel] co-treated with [Cadmium Chloride results in increased abundance of Cadmium]] results in decreased activity of CAT protein]; galangin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased activity of CAT protein]; gamma-glutamylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased activity of CAT protein]; Melatonin inhibits the reaction [Cadmium results in decreased expression of CAT]; naringenin inhibits the reaction [Cadmium results in decreased activity of CAT protein]; pinostrobin inhibits the reaction [Cadmium results in decreased activity of CAT protein]; Plant Extracts inhibits the reaction [Cadmium results in decreased activity of CAT protein]; Plant Preparations promotes the reaction [Cadmium results in increased activity of CAT protein]; Quercetin inhibits the reaction [Cadmium results in decreased activity of CAT protein]; Quercetin inhibits the reaction [Cadmium results in decreased expression of CAT protein]; Silymarin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased activity of CAT protein]; Vitamin E inhibits the reaction [Cadmium results in increased activity of CAT protein]PMID:14535831 PMID:17125799 PMID:17176674 PMID:17698948 PMID:19409769 PMID:19615871 PMID:22008531 PMID:22013727 PMID:22995158 PMID:23543441 PMID:23916567 PMID:31390532 PMID:31639282 PMID:32347499 PMID:34695510 PMID:34767868 PMID:35384154 PMID:35489423 PMID:36718047 PMID:37342552 PMID:37949422
Cataffects expressionISOCat (Mus musculus)6480464CTDCadmium affects the expression of CAT mRNAPMID:26363317
Catdecreases activityISOCAT (Homo sapiens)6480464CTDCadmium results in decreased activity of CAT proteinPMID:18061332
Catdecreases activityISOCat (Mus musculus)6480464CTDCadmium results in decreased activity of CAT proteinPMID:17262218 PMID:37270049
Catincreases activityISOCAT (Homo sapiens)6480464CTDCadmium results in increased activity of CAT proteinPMID:33559965
Catincreases activityISOCat (Mus musculus)6480464CTDCadmium results in increased activity of CAT proteinPMID:26363317
Catincreases expressionISOCat (Mus musculus)6480464CTDCadmium results in increased expression of CAT mRNAPMID:24067728
Catmultiple interactionsISOCAT (Homo sapiens)6480464CTDCAT promotes the reaction [Cadmium results in increased degradation of CASP3 protein]; CAT protein inhibits the reaction [Cadmium results in increased phosphorylation of AKT1 protein]; CAT protein inhibits the reaction [Cadmium results in increased phosphorylation of GSK3B protein]PMID:12538343 PMID:22884995
Catmultiple interactionsISOCat (Mus musculus)6480464CTD[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased activity of CAT protein; CAT protein inhibits the reaction [Cadmium results in increased phosphorylation of STK11 protein]; Curcumin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased activity of CAT protein]; Pioglitazone inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased activity of CAT protein]; Plant Preparations inhibits the reaction [Cadmium results in decreased activity of CAT protein]PMID:17262218 PMID:21767558 PMID:32735850
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