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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2279
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cat
Name: catalase
Acc ID: CHEBI:18723
Term: nicotine
Definition: A racemate composed of equimolar amounts of (R)- and (S)-nicotine.
Chemical ID: MESH:D009538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Catdecreases activityEXP 6480464CTDNicotine results in decreased activity of CAT proteinPMID:10509436 PMID:10906423 PMID:11747978 PMID:23033686 PMID:29972271
Catincreases activityEXP 6480464CTDNicotine results in increased activity of CAT proteinPMID:11747978 PMID:15925865 PMID:25662863
Catmultiple interactionsEXP 6480464CTD[acephate co-treated with methamidophos co-treated with Nicotine] results in increased activity of CAT protein; [Ethanol co-treated with Nicotine] results in decreased activity of CAT protein; [Ethanol co-treated with Nicotine] results in increased activity of CAT protein; Folic Acid inhibits the reaction [Nicotine results in decreased activity of CAT protein]PMID:10874619 PMID:11747978 PMID:29972271
Catdecreases activityISOCat (Mus musculus)6480464CTDNicotine results in decreased activity of CAT proteinPMID:19778253 PMID:30896085
Catmultiple interactionsISOCat (Mus musculus)6480464CTDroyal jelly inhibits the reaction [Nicotine results in decreased activity of CAT protein]PMID:30896085
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