Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2277
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casr
Name: calcium-sensing receptor
Acc ID: CHEBI:15746
Term: spermine
Definition: A polyazaalkane that is tetradecane in which the carbons at positions 1, 5, 10 and 14 are replaced by nitrogens. Spermine has broad actions on cellular metabolism.
Chemical ID: MESH:D013096
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casrmultiple interactionsEXP 6480464CTDNPS R-467 promotes the reaction [Spermine binds to and results in increased activity of CASR protein]; Phenylephrine inhibits the reaction [Spermine binds to and results in increased activity of CASR protein]; Spermine binds to and results in increased activity of CASR protein; Thapsigargin inhibits the reaction [Spermine binds to and results in increased activity of CASR protein]PMID:11071898
Casrmultiple interactionsISOCASR (Homo sapiens)6480464CTD2-aminoethoxydiphenyl borate inhibits the reaction [Spermine binds to and results in increased activity of CASR protein]; [Spermine binds to and results in increased activity of CASR protein] which results in increased uptake of Calcium; Lanthanum inhibits the reaction [Spermine binds to and results in increased activity of CASR protein]; Spermine binds to and results in increased activity of CASR proteinPMID:17041782
Go Back to source page   Continue to Ontology report