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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2274
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp1
Name: caspase 1
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp1increases expressionEXP 6480464CTDDoxorubicin results in increased expression of CASP1 mRNA; Doxorubicin results in increased expression of CASP1 proteinPMID:35764897
Casp1multiple interactionsEXP 6480464CTDHDAC6 protein promotes the reaction [Doxorubicin results in increased expression of CASP1 mRNA]; HDAC6 protein promotes the reaction [Doxorubicin results in increased expression of CASP1 protein]PMID:35764897
Casp1increases expressionISOCasp1 (Mus musculus)6480464CTDDoxorubicin results in increased expression of CASP1 mRNAPMID:26873546
Casp1increases expressionISOCASP1 (Homo sapiens)6480464CTDDoxorubicin results in increased expression of CASP1 mRNA; Doxorubicin results in increased expression of CASP1 protein modified formPMID:16001973 PMID:24885895
Casp1increases response to substanceISOCasp1 (Mus musculus)6480464CTDCASP1 results in increased susceptibility to DoxorubicinPMID:9491796
Casp1multiple interactionsISOCasp1 (Mus musculus)6480464CTD[Doxorubicin co-treated with Dexrazoxane] results in decreased expression of CASP1 mRNAPMID:26873546
Casp1multiple interactionsISOCASP1 (Homo sapiens)6480464CTDMAPK1 promotes the reaction [Doxorubicin results in increased expression of CASP1 protein modified form]PMID:24885895
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