GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Casp1 | increases cleavage | EXP | | 6480464 | CTD | Acrolein results in increased cleavage of CASP1 protein | PMID:31639409 | Casp1 | multiple interactions | EXP | | 6480464 | CTD | ADAM10 protein affects the reaction [Acrolein results in increased cleavage of CASP1 protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [Acrolein results in increased cleavage of CASP1 protein]; SB 203580 inhibits the reaction [Acrolein results in increased cleavage of CASP1 protein] | PMID:31639409 | Casp1 | increases expression | ISO | CASP1 (Homo sapiens) | 6480464 | CTD | Acrolein results in increased expression of CASP1 protein | PMID:34238121 | Casp1 | multiple interactions | ISO | CASP1 (Homo sapiens) | 6480464 | CTD | 3-methyladenine promotes the reaction [[Acrolein co-treated with Lipopolysaccharides] results in increased cleavage of CASP1 protein]; 3-methyladenine promotes the reaction [Acrolein results in increased expression of CASP1 protein]; [Acrolein co-treated with Lipopolysaccharides] results in increased cleavage of CASP1 protein; [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of CASP1 mRNA; [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of CASP1 mRNA; Acetylcysteine inhibits the reaction [[Acrolein co-treated with Lipopolysaccharides] results in increased cleavage of CASP1 protein]; Acetylcysteine inhibits the reaction [Acrolein promotes the reaction [Lipopolysaccharides results in increased expression of and results in increased cleavage of CASP1 protein]]; Acetylcysteine inhibits the reaction [Acrolein results in increased expression of and results in increased cleavage of CASP1 protein]; Acetylcysteine inhibits the reaction [Acrolein results in increased expression of CASP1 protein]; Acetylcysteine inhibits the reaction [Lipopolysaccharides promotes the reaction [Acrolein results in increased expression of and results in increased cleavage of CASP1 protein]]; Acrolein promotes the reaction [Lipopolysaccharides results in increased expression of and results in increased cleavage of CASP1 protein]; Acrolein results in increased expression of and results in increased cleavage of CASP1 protein; ATG7 protein affects the reaction [Acrolein results in increased expression of CASP1 protein]; belnacasan inhibits the reaction [[Acrolein co-treated with Lipopolysaccharides] results in increased cleavage of CASP1 protein]; Lipopolysaccharides promotes the reaction [Acrolein results in increased expression of and results in increased cleavage of CASP1 protein]; NLRP3 protein affects the reaction [[Acrolein co-treated with Lipopolysaccharides] results in increased cleavage of CASP1 protein]; NLRP3 protein affects the reaction [Acrolein results in increased expression of CASP1 protein]; Sirolimus inhibits the reaction [[Acrolein co-treated with Lipopolysaccharides] results in increased cleavage of CASP1 protein] | PMID:30205151 PMID:32699268 PMID:34238121 PMID:36055550 | | ||||||||||||||||||||||
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