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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2240
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Car2
Name: carbonic anhydrase 2
Acc ID: CHEBI:4903
Term: 17alpha-ethynylestradiol
Definition: A 3-hydroxy steroid that is estradiol substituted by a ethynyl group at position 17. It is a xenoestrogen synthesized from estradiol and has been shown to exhibit high estrogenic potency on oral administration.
Chemical ID: MESH:D004997
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Car2decreases expressionEXP 6480464CTDEthinyl Estradiol results in decreased expression of CA2 mRNA; Ethinyl Estradiol results in decreased expression of CAR2 mRNAPMID:16174780 PMID:17557909 PMID:19400957 PMID:24096037 PMID:29097150
Car2increases expressionISOCar2 (Mus musculus)6480464CTDEthinyl Estradiol results in increased expression of CAR2 mRNAPMID:16174780 PMID:17555576 PMID:17942748 PMID:19400957 PMID:24096037
Car2increases expressionISOCA2 (Homo sapiens)6480464CTDEthinyl Estradiol results in increased expression of CA2 mRNAPMID:18936297
Car2multiple interactionsISOCar2 (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CAR2 mRNAPMID:17942748
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