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GENE - TERM ANNOTATION REPORT

RGD ID: 2239
Species: Rattus norvegicus
RGD Object: Gene
Symbol: C8b
Name: complement C8 beta chain
Acc ID: GO:0005579
Term: membrane attack complex
Definition: A protein complex produced by sequentially activated components of the complement cascade inserted into a target cell membrane and forming a pore leading to cell lysis via ion and water flow.
Definition Source(s): GOC:add, ISBN:0198547684, ISBN:068340007X, ISBN:0781735149
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
C8blocated_inISOC8B (Homo sapiens)1624291RGD PMID:30552328

PMID:30552328
C8bpart_ofISOC8B (Homo sapiens)1624291RGD PMID:22832194

PMID:22832194
C8bpart_ofIBAPANTHER:PTN001832474 or UniProtKB:P02748 or UniProtKB:P07357 or UniProtKB:P07358 or UniProtKB:P10643 or UniProtKB:P136711600115GO_CentralGO_REF:0000033

GO_REF:0000033
C8bpart_ofIEAUniProtKB-KW:KW-04731600115UniProtGO_REF:0000043

GO_REF:0000043
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