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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2218
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Brca1
Name: BRCA1, DNA repair associated
Acc ID: CHEBI:17823
Term: calcitriol
Definition: A hydroxycalciol that is calcidiol in which the pro-S hydrogen of calcidiol is replaced by a hydroxy group. It is the active form of vitamin D3, produced fom calciol via hydoxylation in the liver to form calcidiol, which is subsequently oxidised in the kidney to give calcitriol.
Chemical ID: MESH:D002117
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Brca1decreases expressionISOBRCA1 (Homo sapiens)6480464CTDCalcitriol results in decreased expression of BRCA1 mRNAPMID:21592394
Brca1multiple interactionsISOBRCA1 (Homo sapiens)6480464CTD[Testosterone co-treated with Calcitriol] results in decreased expression of BRCA1 mRNA; Calcitriol promotes the reaction [Testosterone results in decreased expression of BRCA1 mRNA]; Testosterone promotes the reaction [Calcitriol results in decreased expression of BRCA1 mRNA]PMID:21592394
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