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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2213
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bmp4
Name: bone morphogenetic protein 4
Acc ID: CHEBI:44185
Term: methotrexate
Definition: A pteridine that has formula C20H22N8O5.
Chemical ID: MESH:D008727
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bmp4affects expressionISOBmp4 (Mus musculus)6480464CTDMethotrexate affects the expression of BMP4 mRNAPMID:18502557
Bmp4decreases response to substanceISOBMP4 (Homo sapiens)6480464CTDBMP4 mRNA results in decreased susceptibility to MethotrexatePMID:20008919
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