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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2211
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bmp2
Name: bone morphogenetic protein 2
Acc ID: CHEBI:94988
Term: N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide
Definition: An organohalogen compound that has formula C15H11Cl2NO3.
Chemical ID: MESH:C531525
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDN-(1, 3-benzodioxol-5-ylmethyl)-2, 6-dichlorobenzamide results in increased expression of BMP2 mRNA, N-(1, 3-benzodioxol-5-ylmethyl)-2, 6-dichlorobenzamide results in increased expression of BMP2 protein

PMID:28017615
multiple interactionsEXP 6480464CTDALDH2 protein affects the reaction [N-(1, 3-benzodioxol-5-ylmethyl)-2, 6-dichlorobenzamide results in increased expression of BMP2 protein], N-(1, 3-benzodioxol-5-ylmethyl)-2, 6-dichlorobenzamide inhibits the reaction [Acetaldehyde results in decreased expression of BMP2 protein], N-(1, 3-benzodioxol-5-ylmethyl)-2, 6-dichlorobenzamide results in increased expression of and results in increased secretion of BMP2 protein

PMID:28017615
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.