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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2211
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bmp2
Name: bone morphogenetic protein 2
Acc ID: CHEBI:28819
Term: naringin
Definition: A disaccharide derivative that is (S)-naringenin substituted by a 2-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage.
Chemical ID: MESH:C005274
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDnaringin results in decreased expression of BMP2 mRNA

PMID:21820093
increases secretionEXP 6480464CTDnaringin results in increased secretion of BMP2 protein

PMID:23596885
multiple interactionsEXP 6480464CTDfulvestrant inhibits the reaction [naringin results in increased secretion of BMP2 protein]

PMID:23596885
increases expressionISORGD:7356026480464CTDnaringin results in increased expression of BMP2 mRNA, naringin results in increased expression of BMP2 protein

PMID:18495116
multiple interactionsISORGD:7356026480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [naringin promotes the reaction [FOS protein binds to BMP2 promoter]], 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [naringin promotes the reaction [JUN protein binds to BMP2 promoter]], FOS protein affects the reaction [naringin results in increased expression of BMP2 mRNA], FOS protein affects the reaction [naringin results in increased expression of BMP2 protein], JUN protein affects the reaction [naringin results in increased expression of BMP2 mRNA], JUN protein affects the reaction [naringin results in increased expression of BMP2 protein], naringin promotes the reaction [FOS protein binds to BMP2 promoter], naringin promotes the reaction [JUN protein binds to BMP2 promoter]

PMID:18495116
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.