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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2206
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bglap
Name: bone gamma-carboxyglutamate protein
Acc ID: CHEBI:16374
Term: menaquinone
Definition: Any member of the class of menaquinones that is 2-methyl-1,4-naphthoquinone with an unsaturated isoprenoid chain at the 3-position.
Chemical ID: MESH:D024482
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bglapincreases secretionEXP 6480464CTDVitamin K 2 results in increased secretion of BGLAP protein modified formPMID:30639440
Bglapmultiple interactionsEXP 6480464CTDPTH protein promotes the reaction [Vitamin K 2 results in increased carboxylation of BGLAP protein]; PTH protein promotes the reaction [Vitamin K 2 results in increased secretion of BGLAP protein modified form]; Vitamin K 2 promotes the reaction [PTH protein results in increased carboxylation of BGLAP protein]; Vitamin K 2 promotes the reaction [PTH protein results in increased secretion of BGLAP protein modified form]; Vitamin K 2 results in increased carboxylation of and results in decreased secretion of BGLAP proteinPMID:30639440
Bglapdecreases expressionISOBGLAP (Homo sapiens)6480464CTDVitamin K 2 results in decreased expression of BGLAP mRNAPMID:19675304
Bglapmultiple interactionsISOBGLAP (Homo sapiens)6480464CTDVitamin K 2 inhibits the reaction [IL1B protein results in decreased expression of BGLAP protein modified form]PMID:20460758
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