GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Bdnf | decreases expression | EXP | | 6480464 | CTD | Lithium results in decreased expression of BDNF mRNA | PMID:21220416 | Bdnf | increases expression | EXP | | 6480464 | CTD | Lithium results in increased expression of BDNF mRNA; Lithium results in increased expression of BDNF protein | PMID:17442489 PMID:9073163 | Bdnf | multiple interactions | EXP | | 6480464 | CTD | Diazepam inhibits the reaction [Lithium results in increased expression of BDNF mRNA]; Lithium inhibits the reaction [Dextroamphetamine results in decreased expression of BDNF protein]; Lithium inhibits the reaction [Ouabain results in decreased expression of BDNF protein] | PMID:16460767 PMID:19954800 PMID:9073163 | Bdnf | affects response to substance | ISO | BDNF (Homo sapiens) | 6480464 | CTD | BDNF gene polymorphism affects the susceptibility to Lithium | PMID:19018715 | Bdnf | increases response to substance | ISO | BDNF (Homo sapiens) | 6480464 | CTD | BDNF protein results in increased susceptibility to Lithium | PMID:19018715 | Bdnf | multiple interactions | ISO | BDNF (Homo sapiens) | 6480464 | CTD | [Lithium Chloride results in increased abundance of Lithium] inhibits the reaction [Paraquat results in decreased expression of BDNF mRNA]; [Lithium Chloride results in increased abundance of Lithium] inhibits the reaction [Paraquat results in decreased secretion of BDNF protein]; [Lithium Chloride results in increased abundance of Lithium] which results in increased expression of BDNF mRNA; [Lithium Chloride results in increased abundance of Lithium] which results in increased secretion of BDNF protein | PMID:26074776 | |
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