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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2202
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bdnf
Name: brain-derived neurotrophic factor
Acc ID: CHEBI:9168
Term: sirolimus
Definition: A macrolide lactam isolated from Streptomyces hygroscopicus consisting of a 29-membered ring containing 4 trans double bonds, three of which are conjugated. It is an antibiotic, immunosupressive and antineoplastic agent.
Chemical ID: MESH:D020123
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bdnfmultiple interactionsISOBdnf (Mus musculus)6480464CTDSirolimus inhibits the reaction [BDNF protein results in increased expression of PPP1R1B mRNA]; Sirolimus inhibits the reaction [BDNF protein results in increased expression of PPP1R1B protein]; Sirolimus inhibits the reaction [Creatine results in increased expression of BDNF protein]; Sirolimus inhibits the reaction [Ketamine results in increased expression of BDNF protein]PMID:17209049 PMID:33022268
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