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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2200
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bcl2l1
Name: Bcl2-like 1
Acc ID: CHEBI:9288
Term: streptozocin
Definition: An N-nitrosourea that is an antibiotic produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Chemical ID: MESH:D013311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2l1decreases expressionEXP 6480464CTDStreptozocin results in decreased expression of BCL2L1 mRNA; Streptozocin results in decreased expression of BCL2L1 proteinPMID:16595661 PMID:18758938 PMID:28856781 PMID:35414346
Bcl2l1increases expressionEXP 6480464CTDStreptozocin results in increased expression of BCL2L1 proteinPMID:15976052 PMID:19682444
Bcl2l1multiple interactionsEXP 6480464CTDAnthocyanins inhibits the reaction [Streptozocin results in decreased expression of BCL2L1 protein]; arjunolic acid inhibits the reaction [Streptozocin results in increased expression of BCL2L1 protein]; Ascorbic Acid inhibits the reaction [Streptozocin results in decreased expression of BCL2L1 protein]; cobaltiprotoporphyrin inhibits the reaction [Streptozocin results in decreased expression of BCL2L1 protein]; Metformin inhibits the reaction [Streptozocin results in increased expression of BCL2L1 mRNA]; morin inhibits the reaction [Streptozocin results in increased expression of BCL2L1 mRNA]; tin mesoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [Streptozocin results in decreased expression of BCL2L1 protein]]PMID:16595661 PMID:18758938 PMID:19682444 PMID:28856781 PMID:35414346
Bcl2l1decreases expressionISOBcl2l1 (Mus musculus)6480464CTDStreptozocin results in decreased expression of BCL2L1 mRNAPMID:24781736
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