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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2199
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bcl2
Name: BCL2, apoptosis regulator
Acc ID: CHEBI:4489
Term: Diallyl sulfide
Definition: An organic sulfide that has formula C6H10S.
Chemical ID: MESH:C038491
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2multiple interactionsEXP 6480464CTDallyl sulfide inhibits the reaction [Ethylene Chlorohydrin results in decreased expression of BCL2 protein]; allyl sulfide promotes the reaction [Bleomycin results in increased expression of BCL2 protein]PMID:23656969 PMID:31585129
Bcl2decreases expressionISOBCL2 (Homo sapiens)6480464CTDallyl sulfide results in decreased expression of BCL2 mRNA; allyl sulfide results in decreased expression of BCL2 proteinPMID:17647244 PMID:34724321
Bcl2multiple interactionsISOBCL2 (Homo sapiens)6480464CTD[allyl sulfide co-treated with Resveratrol] results in decreased expression of BCL2 mRNA; allyl sulfide inhibits the reaction [Estradiol results in increased expression of BCL2 protein]; ESR1 protein alternative form promotes the reaction [allyl sulfide inhibits the reaction [Estradiol results in increased expression of BCL2 protein]]PMID:18512326 PMID:34724321
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