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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2199
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bcl2
Name: BCL2, apoptosis regulator
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2affects expressionEXP 6480464CTDDoxorubicin affects the expression of BCL2 mRNA; Doxorubicin affects the expression of BCL2 proteinPMID:24742701 PMID:32652078
Bcl2decreases expressionEXP 6480464CTDDoxorubicin results in decreased expression of BCL2 mRNA; Doxorubicin results in decreased expression of BCL2 proteinPMID:12505058 PMID:14736733 PMID:15380674 PMID:17234320 PMID:17582587 PMID:17924179 PMID:18400355 PMID:18611398 PMID:18632596 PMID:18775851 PMID:21194538 PMID:22015447 PMID:22155320 PMID:24072175 PMID:24902966 PMID:25169008 PMID:26036690 PMID:26678157 PMID:26818447 PMID:27087047 PMID:28495616 PMID:29087013 PMID:30009776 PMID:30377735 PMID:30836069 PMID:30885636 PMID:30928397 PMID:31100273 PMID:31376360 PMID:32810592 PMID:34273911 PMID:34296331 PMID:34343525 PMID:34605098 PMID:34713381 PMID:34813134 PMID:35093381 PMID:35134463 PMID:35137609 PMID:35438302 PMID:35524977 PMID:35979984 PMID:37499777
Bcl2increases expressionEXP 6480464CTDDoxorubicin results in increased expression of BCL2 proteinPMID:11291592 PMID:17520333 PMID:19890356
Bcl2multiple interactionsEXP 6480464CTD2,3,5,4'-tetrahydroxystilbene 2-O-glucopyranoside promotes the reaction [Doxorubicin results in increased expression of BCL2 protein]; 4-(((4-carboxybutyl) (2- (5-fluoro-2-((4'-(trifluoromethyl) biphenyl-4-yl)methoxy)phenyl)ethyl) amino)methyl)benzoic acid affects the reaction [Doxorubicin affects the expression of BCL2 protein]; [Doxorubicin co-treated with paeonol] results in increased expression of BCL2 mRNA; [Doxorubicin co-treated with ZFP260 protein] results in increased expression of BCL2 protein; Amlodipine inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; Carvedilol inhibits the reaction [Doxorubicin results in decreased expression of BCL2 mRNA]; Carvedilol inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; caryophyllene inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; Catechin inhibits the reaction [Doxorubicin results in decreased expression of BCL2 mRNA]; Catechin inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; Chitosan analog inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; chloroquine diphosphate promotes the reaction [Doxorubicin inhibits the reaction [Thioacetamide results in increased expression of BCL2 mRNA]]; citronellal inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; coenzyme Q10 inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; corilagin inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; corosolic acid inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; dapagliflozin inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; diallyl trisulfide inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; Doxorubicin inhibits the reaction [Thioacetamide results in increased expression of BCL2 mRNA]; Doxorubicin promotes the reaction [chloroquine diphosphate inhibits the reaction [Thioacetamide results in increased expression of BCL2 mRNA]]; Doxorubicin promotes the reaction [TP53 protein binds to BCL2 promoter]; Drugs, Chinese Herbal inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; EPO protein inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; Exenatide inhibits the reaction [Doxorubicin results in decreased expression of BCL2 mRNA]; Febuxostat inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; geraniol inhibits the reaction [Doxorubicin results in decreased expression of BCL2 mRNA]; GHRL protein inhibits the reaction [Doxorubicin results in decreased expression of BCL2 mRNA]; Ginkgo biloba extract inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; iodopravadoline inhibits the reaction [caryophyllene inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]]; Lithium Chloride inhibits the reaction [citronellal inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]]; Melatonin inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; Metformin inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; morin inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; necrostatin-1 inhibits the reaction [Doxorubicin results in decreased expression of BCL2 mRNA]; Nicorandil inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; Phenylephrine inhibits the reaction [Doxorubicin results in decreased expression of BCL2 mRNA]; pifithrin inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; PRKAA2 protein promotes the reaction [corosolic acid inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]]; Proanthocyanidins inhibits the reaction [Doxorubicin results in decreased expression of BCL2 mRNA]; Proanthocyanidins inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; Propofol inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; Quercetin inhibits the reaction [Doxorubicin results in decreased expression of BCL2 mRNA]; Quercetin inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; rhodioloside inhibits the reaction [Doxorubicin results in decreased expression of BCL2 mRNA]; salvianolic acid B inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; SC-66 compound inhibits the reaction [SIRT4 protein inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]]; SIRT4 protein inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; Sitagliptin Phosphate inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; STAT3 protein promotes the reaction [dapagliflozin inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]]; TDRG1 protein affects the reaction [Doxorubicin results in decreased expression of BCL2 protein]; TFEB protein promotes the reaction [corosolic acid inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]]; TNF protein affects the reaction [GHRL protein inhibits the reaction [Doxorubicin results in decreased expression of BCL2 mRNA]]; U 0126 inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; Valsartan inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; Verteporfin inhibits the reaction [Melatonin inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]]; Vitamin E inhibits the reaction [Doxorubicin results in decreased expression of BCL2 mRNA]; Withanolides inhibits the reaction [Doxorubicin results in increased expression of BCL2 protein]; YAP1 protein affects the reaction [Melatonin inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]]PMID:15380674 PMID:17234320 PMID:17520333 PMID:17582587 PMID:17924179 PMID:18400355 PMID:18611398 PMID:18632596 PMID:18775851 PMID:19890356 PMID:22015447 PMID:22155320 PMID:24072175 PMID:24902966 PMID:26036690 PMID:26818447 PMID:27087047 PMID:28495616 PMID:29087013 PMID:29133031 PMID:30836069 PMID:30885636 PMID:30928397 PMID:31100273 PMID:31307187 PMID:31376360 PMID:32652078 PMID:32810592 PMID:34273911 PMID:34296331 PMID:34343525 PMID:34605098 PMID:34813134 PMID:35093381 PMID:35134463 PMID:35137609 PMID:35438302 PMID:35524977 PMID:35979984
Bcl2affects expressionISOBCL2 (Homo sapiens)6480464CTDDoxorubicin affects the expression of BCL2 mRNAPMID:16705698 PMID:23792648 PMID:27780733
Bcl2affects response to substanceISOBCL2 (Homo sapiens)6480464CTDBCL2 protein affects the susceptibility to DoxorubicinPMID:16322301 PMID:16450387 PMID:17541305
Bcl2decreases expressionISOBcl2 (Mus musculus)6480464CTDDoxorubicin results in decreased expression of BCL2 mRNA; Doxorubicin results in decreased expression of BCL2 proteinPMID:15811867 PMID:17673183 PMID:18627295 PMID:20543097 PMID:22763982 PMID:25896364 PMID:29481770 PMID:29653124 PMID:30734460 PMID:30885636 PMID:31158416 PMID:32068018 PMID:34296331 PMID:34713381 PMID:35134463 PMID:36639017 PMID:36811345 PMID:36925030
Bcl2decreases expressionISOBCL2 (Homo sapiens)6480464CTDDoxorubicin results in decreased expression of BCL2 mRNA; Doxorubicin results in decreased expression of BCL2 proteinPMID:11779855 PMID:12505058 PMID:16001973 PMID:16890185 PMID:17404015 PMID:17542780 PMID:17959036 PMID:18560228 PMID:19746155 PMID:25339540 PMID:26969377 PMID:29341321 PMID:29803840 PMID:31207345 PMID:31563593 PMID:31843629 PMID:32128952 PMID:33507000 PMID:34719826 PMID:36442531 PMID:37406984
Bcl2decreases response to substanceISOBCL2 (Homo sapiens)6480464CTDBCL2 protein results in decreased susceptibility to DoxorubicinPMID:8781438
Bcl2increases expressionISOBcl2 (Mus musculus)6480464CTDDoxorubicin results in increased expression of BCL2 mRNAPMID:15505089 PMID:19714248 PMID:26873546
Bcl2increases expressionISOBCL2 (Homo sapiens)6480464CTDDoxorubicin results in increased expression of BCL2 mRNA; Doxorubicin results in increased expression of BCL2 proteinPMID:15571967 PMID:15939500 PMID:19270784 PMID:19757172 PMID:8781438
Bcl2multiple interactionsISOBcl2 (Mus musculus)6480464CTD[Zoledronic Acid co-treated with Doxorubicin] results in decreased expression of BCL2 protein; BDKRB1 protein affects the reaction [Doxorubicin results in decreased expression of BCL2 protein]; corosolic acid inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; Doxorubicin inhibits the reaction [Quercetin results in decreased expression of BCL2 protein]; Doxorubicin promotes the reaction [Hesperidin results in decreased expression of BCL2 mRNA]; Doxycycline inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; Exenatide inhibits the reaction [Doxorubicin results in decreased expression of BCL2 mRNA]; Genistein inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; Nanotubes, Carbon inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; naringin inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; PSMB10 protein inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; PSMB8 protein inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; PSMB9 protein inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; Resveratrol affects the reaction [Doxorubicin results in decreased expression of BCL2 protein]; Resveratrol inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; SC-66 compound inhibits the reaction [SIRT4 protein inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]]; Sildenafil Citrate inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; Sirolimus inhibits the reaction [SIRT4 protein inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]]; SIRT4 protein inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; Tadalafil inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; zinc chloride inhibits the reaction [Doxorubicin results in increased expression of BCL2 mRNA]; zinc protoporphyrin inhibits the reaction [Resveratrol inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]]PMID:15538571 PMID:15811867 PMID:17673183 PMID:18627295 PMID:19714248 PMID:19789217 PMID:20543097 PMID:22763982 PMID:25896364 PMID:29481770 PMID:30734460 PMID:30885636 PMID:32068018 PMID:34296331 PMID:35134463 PMID:36811345 PMID:36925030
Bcl2multiple interactionsISOBCL2 (Homo sapiens)6480464CTD[[[Doxorubicin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased phosphorylation of ABL1 protein] which results in increased expression of TP73 protein] which results in decreased expression of BCL2 protein; [[Doxorubicin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein] which results in decreased expression of BCL2 mRNA; [[Doxorubicin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein] which results in decreased expression of BCL2 protein; [[F3 protein co-treated with F7 protein] results in increased expression of BCL2 protein] which results in decreased susceptibility to Doxorubicin; [Amifostine co-treated with Doxorubicin] results in decreased expression of BCL2 mRNA; [Arsenic Trioxide co-treated with Doxorubicin co-treated with Magnetite Nanoparticles analog] affects the expression of BCL2 mRNA; [Arsenic Trioxide co-treated with Doxorubicin co-treated with Magnetite Nanoparticles analog] affects the expression of BCL2 protein; [Doxorubicin co-treated with bisphenol A] results in increased expression of BCL2 protein; [Doxorubicin co-treated with Curcumin] results in decreased expression of BCL2 mRNA; [Doxorubicin co-treated with Cyclophosphamide] affects the expression of BCL2 mRNA; [Doxorubicin co-treated with Dexamethasone co-treated with Vincristine co-treated with Cytarabine co-treated with Mercaptopurine co-treated with Methotrexate co-treated with Cyclophosphamide co-treated with Enzymes and Coenzymes] results in increased expression of BCL2 protein; [Doxorubicin co-treated with Melatonin] results in decreased expression of BCL2 protein; [Doxorubicin co-treated with Resveratrol] results in decreased expression of BCL2 mRNA; [Doxorubicin co-treated with Resveratrol] results in decreased expression of BCL2 protein; [Doxorubicin co-treated with Vincristine co-treated with Etoposide co-treated with Mitotane] results in decreased expression of BCL2 protein; [Estradiol results in increased expression of BCL2 mRNA] which results in increased susceptibility to Doxorubicin; [F3 protein affects the expression of BCL2 protein] which affects the susceptibility to Doxorubicin; [germacrone results in increased susceptibility to Doxorubicin] which results in decreased expression of BCL2; [Oleanolic Acid results in increased susceptibility to Doxorubicin] which affects the expression of BCL2 mRNA; [YAP1 protein promotes the reaction [[Doxorubicin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein]] which results in decreased expression of BCL2 protein; Acetylcysteine inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; BCL2 protein inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased cleavage of and results in increased activity of and results in increased localization of BID protein]]; BCL2 protein inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased cleavage of CASP3 protein]]; BCL2 protein inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased cleavage of CASP8 protein]]; BCL2 protein inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased cleavage of CASP9 protein]]; BCL2 protein inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased expression of and results in increased activity of BAX protein]]; BCL2 protein inhibits the reaction [PI103 promotes the reaction [Doxorubicin results in increased cleavage of and results in increased activity of and results in increased localization of BID protein]]; BCL2 protein inhibits the reaction [PI103 promotes the reaction [Doxorubicin results in increased cleavage of CASP3 protein]]; BCL2 protein inhibits the reaction [PI103 promotes the reaction [Doxorubicin results in increased cleavage of CASP8 protein]]; BCL2 protein inhibits the reaction [PI103 promotes the reaction [Doxorubicin results in increased cleavage of CASP9 protein]]; BCL2 protein inhibits the reaction [PI103 promotes the reaction [Doxorubicin results in increased expression of and results in increased activity of BAX protein]]; BCL2 protein results in decreased susceptibility to [Doxorubicin co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one]; BCL2 protein results in decreased susceptibility to [Doxorubicin co-treated with PI103]; Doxorubicin promotes the reaction [Melatonin results in decreased expression of BCL2 mRNA]; Doxorubicin promotes the reaction [Paclitaxel results in increased phosphorylation of BCL2 protein]; Folic Acid inhibits the reaction [Doxorubicin results in decreased expression of BCL2 mRNA]; GSTA1 protein inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; HIF1A protein affects the reaction [IL6 protein inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]]; IFNA1 protein promotes the reaction [Doxorubicin results in decreased expression of BCL2 protein]; IL6 protein inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; Loperamide promotes the reaction [Doxorubicin results in decreased expression of BCL2 mRNA]; Morphine inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; NORAD inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; pluronic block copolymer p85 inhibits the reaction [Doxorubicin results in increased expression of BCL2 mRNA]; PRKAR2B protein inhibits the reaction [TDRG1 protein affects the reaction [Doxorubicin results in decreased expression of BCL2 protein]]; Sirolimus inhibits the reaction [Doxorubicin results in increased expression of BCL2 protein]; Tamoxifen promotes the reaction [Doxorubicin results in increased expression of BCL2 mRNA]PMID:15571967 PMID:15939500 PMID:15985719 PMID:16168113 PMID:16322899 PMID:16890185 PMID:17542780 PMID:17959036 PMID:18325115 PMID:19270784 PMID:19757172 PMID:20333787 PMID:20856197 PMID:21182165 PMID:21214929 PMID:24738333 PMID:26969377 PMID:28323900 PMID:29341321 PMID:29655913 PMID:30581319 PMID:31563593 PMID:32128952 PMID:33507000 PMID:34719826 PMID:35524977 PMID:37345903 PMID:37406984 PMID:9815696
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