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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2199
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bcl2
Name: BCL2, apoptosis regulator
Acc ID: CHEBI:28088
Term: genistein
Definition: A 7-hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties.
Chemical ID: MESH:D019833
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2decreases expressionEXP 6480464CTDGenistein results in decreased expression of BCL2 mRNAPMID:21782745
Bcl2multiple interactionsEXP 6480464CTDGenistein inhibits the reaction [Ethanol results in increased expression of BCL2 mRNA]; Genistein inhibits the reaction [lead acetate results in decreased expression of BCL2 protein]PMID:23274713 PMID:26797587
Bcl2decreases expressionISOBcl2 (Mus musculus)6480464CTDGenistein results in decreased expression of BCL2 mRNA; Genistein results in decreased expression of BCL2 proteinPMID:21078540 PMID:31593742
Bcl2decreases expressionISOBCL2 (Homo sapiens)6480464CTDGenistein results in decreased expression of BCL2 proteinPMID:12791511 PMID:20219070 PMID:21078540
Bcl2increases expressionISOBcl2 (Mus musculus)6480464CTDGenistein results in increased expression of BCL2 mRNAPMID:30056207
Bcl2multiple interactionsISOBcl2 (Mus musculus)6480464CTD[Genistein co-treated with Arsenic Trioxide] results in decreased expression of BCL2 protein; Genistein inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]PMID:21078540 PMID:30734460
Bcl2multiple interactionsISOBCL2 (Homo sapiens)6480464CTD[ASRGL1 protein co-treated with Genistein] results in decreased expression of BCL2 protein; [Calcitriol co-treated with Genistein] results in decreased expression of BCL2 mRNA; [Genistein co-treated with Arsenic Trioxide] results in decreased expression of BCL2 protein; [Genistein co-treated with TNFSF10 protein] results in decreased expression of BCL2 protein; Arsenic Trioxide promotes the reaction [Genistein results in decreased expression of BCL2 protein]; Genistein inhibits the reaction [Paclitaxel results in increased phosphorylation of BCL2 protein]; Genistein inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of BCL2 protein]; Genistein promotes the reaction [Arsenic Trioxide results in decreased expression of BCL2 protein]PMID:15288519 PMID:15907805 PMID:15955619 PMID:19497411 PMID:20219070 PMID:21078540 PMID:33347704
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