GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Bcl2 | decreases expression | EXP | | 6480464 | CTD | Cocaine results in decreased expression of BCL2 mRNA; Cocaine results in decreased expression of BCL2 protein | PMID:11392460 PMID:15365088 PMID:15685203 PMID:19183502 | Bcl2 | increases expression | EXP | | 6480464 | CTD | Cocaine results in increased expression of BCL2 protein | PMID:17084983 PMID:18974856 | Bcl2 | increases phosphorylation | EXP | | 6480464 | CTD | Cocaine results in increased phosphorylation of BCL2 protein | PMID:19879923 | Bcl2 | multiple interactions | EXP | | 6480464 | CTD | 6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [Cocaine results in increased phosphorylation of BCL2 protein]; 7-(hydroxyimino)cyclopropan(b)chromen-1a-carbxoylic acid ethyl ester inhibits the reaction [Cocaine results in increased phosphorylation of BCL2 protein]; Dizocilpine Maleate inhibits the reaction [Cocaine results in increased phosphorylation of BCL2 protein]; ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate inhibits the reaction [Cocaine results in increased phosphorylation of BCL2 protein]; SCH 23390 inhibits the reaction [Cocaine results in increased phosphorylation of BCL2 protein] | PMID:19879923 | Bcl2 | affects expression | ISO | Bcl2 (Mus musculus) | 6480464 | CTD | Cocaine affects the expression of BCL2 mRNA | PMID:15681117 | Bcl2 | decreases expression | ISO | Bcl2 (Mus musculus) | 6480464 | CTD | Cocaine results in decreased expression of BCL2 protein | PMID:29673861 PMID:30393195 | Bcl2 | multiple interactions | ISO | Bcl2 (Mus musculus) | 6480464 | CTD | IL6 protein affects the reaction [Cocaine results in decreased expression of BCL2 protein]; PRKCD protein affects the reaction [Cocaine results in decreased expression of BCL2 protein]; rottlerin inhibits the reaction [Cocaine results in decreased expression of BCL2 protein]; TNF protein affects the reaction [Cocaine results in decreased expression of BCL2 protein]; TNF protein affects the reaction [IL6 protein affects the reaction [Cocaine results in decreased expression of BCL2 protein]] | PMID:29673861 PMID:30393195 | | ||||||||||||||||||||||
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