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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2199
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bcl2
Name: BCL2, apoptosis regulator
Acc ID: CHEBI:27744
Term: glyphosate
Definition: A phosphonic acid resulting from the formal oxidative coupling of the methyl group of methylphosphonic acid with the amino group of glycine. It is one of the most commonly used herbicides worldwide, and the only one to target the enzyme 5-enolpyruvyl-3-shikimate phosphate synthase (EPSPS).
Chemical ID: MESH:C010974
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2multiple interactionsEXP 6480464CTD[Surface-Active Agents co-treated with Glyphosate] results in decreased expression of BCL2 proteinPMID:23099315
Bcl2decreases expressionISOBcl2 (Mus musculus)6480464CTDGlyphosate results in decreased expression of BCL2 mRNA; Glyphosate results in decreased expression of BCL2 proteinPMID:29908847 PMID:31352102
Bcl2decreases expressionISOBCL2 (Homo sapiens)6480464CTDGlyphosate results in decreased expression of BCL2 mRNA; Glyphosate results in decreased expression of BCL2 proteinPMID:30907447 PMID:31874349
Bcl2increases expressionISOBcl2 (Mus musculus)6480464CTDGlyphosate results in increased expression of BCL2 mRNAPMID:30785197
Bcl2increases expressionISOBCL2 (Homo sapiens)6480464CTDGlyphosate results in increased expression of BCL2 mRNA; Glyphosate results in increased expression of BCL2 proteinPMID:24073338 PMID:31751608
Bcl2multiple interactionsISOBCL2 (Homo sapiens)6480464CTD[[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Cisplatin] which results in increased expression of BCL2 mRNA; [[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Cisplatin] which results in increased expression of BCL2 protein; [[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Fluorouracil] which results in increased expression of BCL2 mRNA; [[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Fluorouracil] which results in increased expression of BCL2 proteinPMID:32800223
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