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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2199
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bcl2
Name: BCL2, apoptosis regulator
Acc ID: CHEBI:17846
Term: (S)-naringenin
Definition: The (S)-enantiomer of naringenin.
Chemical ID: MESH:C005273
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2multiple interactionsEXP 6480464CTDnaringenin inhibits the reaction [Glucose results in decreased expression of BCL2 mRNA]; naringenin inhibits the reaction [Glucose results in decreased expression of BCL2 protein]PMID:23192364
Bcl2decreases expressionISOBCL2 (Homo sapiens)6480464CTDnaringenin results in decreased expression of BCL2 mRNAPMID:30153467 PMID:36235125
Bcl2decreases response to substanceISOBCL2 (Homo sapiens)6480464CTDBCL2 protein results in decreased susceptibility to naringeninPMID:19124070
Bcl2multiple interactionsISOBCL2 (Homo sapiens)6480464CTD[naringenin co-treated with bisphenol A] results in increased expression of BCL2 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of BCL2 mRNA; ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate inhibits the reaction [BCL2 protein results in decreased susceptibility to naringenin]; naringenin inhibits the reaction [Pyruvaldehyde results in decreased expression of BCL2 protein]; naringenin promotes the reaction [Tamoxifen results in decreased expression of BCL2 mRNA]PMID:19124070 PMID:30153467 PMID:31254498 PMID:36235125
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