GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Bcl2 | affects expression | ISO | Bcl2 (Mus musculus) | 6480464 | CTD | Nitric Oxide affects the expression of BCL2 mRNA | PMID:17135264 | Bcl2 | decreases expression | ISO | BCL2 (Homo sapiens) | 6480464 | CTD | Nitric Oxide results in decreased expression of BCL2 protein | PMID:15126337 | Bcl2 | multiple interactions | ISO | Bcl2 (Mus musculus) | 6480464 | CTD | [3,5-dimethoxy-4'-hydroxystilbene results in decreased expression of NOS2 mRNA] inhibits the reaction [Nitric Oxide results in increased expression of BCL2 mRNA]; [linsidomine results in increased abundance of Nitric Oxide] which results in increased expression of BCL2 mRNA; [linsidomine results in increased abundance of Nitric Oxide] which results in increased expression of BCL2 protein; [Quercetin results in decreased expression of NOS2 mRNA] inhibits the reaction [Nitric Oxide results in increased expression of BCL2 mRNA] | PMID:17135264 PMID:7706495 | Bcl2 | multiple interactions | ISO | BCL2 (Homo sapiens) | 6480464 | CTD | 1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [Nitric Oxide results in increased nitrosation of and results in decreased degradation of BCL2 protein]; [S-Nitrosoglutathione results in increased abundance of Nitric Oxide] which results in decreased expression of BCL2 protein; Nitric Oxide results in increased nitrosation of and results in decreased degradation of BCL2 protein; pimagedine inhibits the reaction [Nitric Oxide results in increased nitrosation of and results in decreased degradation of BCL2 protein] | PMID:10828028 PMID:16980304 | | ||||||||||||||||||||||
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