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GENE - TERM ANNOTATION REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: GO:0070059
Term: intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
Definition: The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to a stimulus indicating endoplasmic reticulum (ER) stress, and ends when the execution phase of apoptosis is triggered. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen.
Definition Source(s): GOC:mah, GOC:mtg_apoptosis, PMID:18701708
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxacts_upstream_of_or_withinISOBax (Mus musculus)1624291RGDMGI:1097161 UniProtKB:P10415 PMID:12847083 PMID:15776018

PMID:12847083 PMID:15776018
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