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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:78492
Term: diallyl trisulfide
Definition: An organic trisulfide that is trisulfane in which both of the hydrogens are replaced by allyl groups. A component of the essential oil of garlic and a major component of the traditional Chinese medicine allitridium, it exhibits antifungal, antitumour and antioxidant activity
Chemical ID: MESH:C042577
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxmultiple interactionsEXP 6480464CTDdiallyl trisulfide inhibits the reaction [Doxorubicin results in increased expression of BAX protein]PMID:29087013
Baxincreases activityISOBAX (Homo sapiens)6480464CTDdiallyl trisulfide results in increased activity of BAX proteinPMID:23412769
Baxincreases expressionISOBAX (Homo sapiens)6480464CTDdiallyl trisulfide results in increased expression of BAX mRNA; diallyl trisulfide results in increased expression of BAX proteinPMID:19823037 PMID:23754639 PMID:24415872 PMID:24460275
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTDdiallyl trisulfide inhibits the reaction [Glucose results in increased expression of BAX protein]PMID:31115753
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