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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:7719
Term: ochratoxin A
Definition: A phenylalanine derivative resulting from the formal condensation of the amino group of L-phenylalanine with the carboxy group of (3R)-5-chloro-8-hydroxy-3-methyl-1-oxo-3,4-dihydro-1H-2-benzopyran-7-carboxylic acid (ochratoxin alpha). It is among the most widely occurring food-contaminating mycotoxins, produced by Aspergillus ochraceus, Aspergillus carbonarius and Penicillium verrucosum.
Chemical ID: MESH:C025589
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxincreases expressionEXP 6480464CTDochratoxin A results in increased expression of BAX mRNAPMID:23208426
Baxaffects localizationISOBAX (Homo sapiens)6480464CTDochratoxin A affects the localization of BAX proteinPMID:20549612
Baxdecreases expressionISOBAX (Homo sapiens)6480464CTDochratoxin A results in decreased expression of BAX mRNA; ochratoxin A results in decreased expression of BAX proteinPMID:19367635 PMID:24755393
Baxincreases expressionISOBax (Mus musculus)6480464CTDochratoxin A results in increased expression of BAX mRNAPMID:36397609
Baxincreases expressionISOBAX (Homo sapiens)6480464CTDochratoxin A results in increased expression of BAX mRNA; ochratoxin A results in increased expression of BAX proteinPMID:20549612 PMID:31154016 PMID:33465424 PMID:34101318 PMID:34126166 PMID:36587836
Baxincreases response to substanceISOBAX (Homo sapiens)6480464CTDBAX protein results in increased susceptibility to ochratoxin APMID:20549612
Baxmultiple interactionsISOBax (Mus musculus)6480464CTD[fumonisin B1 co-treated with ochratoxin A] results in increased expression of BAX protein; fumonisin B1 promotes the reaction [ochratoxin A results in increased expression of BAX mRNA]PMID:36397609
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTD[Aflatoxin M1 co-treated with ochratoxin A] results in increased expression of BAX protein; BNIP3L protein inhibits the reaction [ochratoxin A results in decreased expression of BAX mRNA]; Oleanolic Acid inhibits the reaction [ochratoxin A results in increased expression of BAX protein]; TRAP1 protein affects the reaction [ochratoxin A results in increased expression of BAX protein]; TRAP1 protein affects the reaction [Oleanolic Acid inhibits the reaction [ochratoxin A results in increased expression of BAX protein]]; Ursolic Acid inhibits the reaction [ochratoxin A results in increased expression of BAX protein]PMID:24755393 PMID:33465424 PMID:34126166 PMID:36587836
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