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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:7596
Term: nitroprusside
Definition: An iron coordination entity that has formula C5FeN6O.
Chemical ID: MESH:D009599
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxaffects localizationEXP 6480464CTDNitroprusside affects the localization of BAX proteinPMID:15961378
Baxincreases expressionEXP 6480464CTDNitroprusside results in increased expression of BAX proteinPMID:10203697
Baxmultiple interactionsEXP 6480464CTDFGF2 protein inhibits the reaction [Nitroprusside results in increased expression of BAX protein]; IGF1 protein inhibits the reaction [Nitroprusside results in increased expression of BAX protein]PMID:10203697
Baxincreases expressionISOBAX (Homo sapiens)6480464CTDNitroprusside results in increased expression of BAX; Nitroprusside results in increased expression of BAX proteinPMID:22178905 PMID:23665936
Baxmultiple interactionsISOBax (Mus musculus)6480464CTD[Nitroprusside results in increased abundance of Nitric Oxide] which affects the localization of BAX protein; SB 203580 inhibits the reaction [[Nitroprusside results in increased abundance of Nitric Oxide] which affects the localization of BAX protein]PMID:22878015
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ursodeoxycholic Acid inhibits the reaction [Nitroprusside affects the localization of BAX protein]]; Nitroprusside results in increased expression of and affects the localization of BAX protein; triciribine inhibits the reaction [Ursodeoxycholic Acid inhibits the reaction [Nitroprusside affects the localization of BAX protein]]; Ursodeoxycholic Acid inhibits the reaction [Nitroprusside results in increased expression of and affects the localization of BAX protein]PMID:22178905
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