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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:72544
Term: flavonoids
Definition: Any organic molecular entity whose stucture is based on derivatives of a phenyl-substituted 1-phenylpropane possessing a C15 or C16 skeleton, or such a structure which is condensed with a C6-C3 lignan precursors. The term is a 'superclass' comprising all members of the classes of flavonoid, isoflavonoid, neoflavonoid, chalcones, dihydrochalcones, aurones, pterocarpan, coumestans, rotenoid, flavonolignan, homoflavonoid and flavonoid oligomers. Originally restricted to natural products, the term is also applied to synthetic compounds related to them.
Chemical ID: MESH:D005419
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxincreases expressionISOBAX (Homo sapiens)6480464CTDFlavonoids results in increased expression of BAX proteinPMID:23063593 PMID:28811126
Baxmultiple interactionsISOBax (Mus musculus)6480464CTDFlavonoids inhibits the reaction [Carbon Tetrachloride results in increased expression of BAX mRNA]PMID:23279844
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTDFlavonoids inhibits the reaction [AGT protein results in increased expression of BAX mRNA]; Flavonoids inhibits the reaction [AGT protein results in increased expression of BAX protein]; Flavonoids inhibits the reaction [BCL2 mutant form promotes the reaction [AGT protein results in increased expression of BAX mRNA]]PMID:23994555
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