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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:6842
Term: methoxychlor
Definition: An organochlorine insecticide that has formula C16H15Cl3O2.
Chemical ID: MESH:D008731
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxaffects response to substanceISOBax (Mus musculus)6480464CTDBAX protein affects the susceptibility to MethoxychlorPMID:14973267
Baxdecreases expressionISOBax (Mus musculus)6480464CTDMethoxychlor metabolite results in decreased expression of BAX protein; Methoxychlor results in decreased expression of BAX proteinPMID:15525693
Baxdecreases expressionISOBAX (Homo sapiens)6480464CTDMethoxychlor results in decreased expression of BAX mRNA; Methoxychlor results in decreased expression of BAX proteinPMID:24835555
Baxincreases expressionISOBax (Mus musculus)6480464CTDMethoxychlor results in increased expression of BAX mRNA; Methoxychlor results in increased expression of BAX proteinPMID:14973267 PMID:16081520 PMID:23000595
Baxmultiple interactionsISOBax (Mus musculus)6480464CTD[ESR1 gene mutant form results in increased susceptibility to Methoxychlor] which results in increased expression of BAX mRNAPMID:22306526
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTDfulvestrant inhibits the reaction [Methoxychlor results in decreased expression of BAX mRNA]PMID:24835555
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