GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Bax | affects response to substance | ISO | Bax (Mus musculus) | 6480464 | CTD | BAX protein affects the susceptibility to Methoxychlor | PMID:14973267 | Bax | decreases expression | ISO | Bax (Mus musculus) | 6480464 | CTD | Methoxychlor metabolite results in decreased expression of BAX protein; Methoxychlor results in decreased expression of BAX protein | PMID:15525693 | Bax | decreases expression | ISO | BAX (Homo sapiens) | 6480464 | CTD | Methoxychlor results in decreased expression of BAX mRNA; Methoxychlor results in decreased expression of BAX protein | PMID:24835555 | Bax | increases expression | ISO | Bax (Mus musculus) | 6480464 | CTD | Methoxychlor results in increased expression of BAX mRNA; Methoxychlor results in increased expression of BAX protein | PMID:14973267 PMID:16081520 PMID:23000595 | Bax | multiple interactions | ISO | Bax (Mus musculus) | 6480464 | CTD | [ESR1 gene mutant form results in increased susceptibility to Methoxychlor] which results in increased expression of BAX mRNA | PMID:22306526 | Bax | multiple interactions | ISO | BAX (Homo sapiens) | 6480464 | CTD | fulvestrant inhibits the reaction [Methoxychlor results in decreased expression of BAX mRNA] | PMID:24835555 | |
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