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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:67850
Term: cudraflavone B
Definition: An extended flavonoid that consists of a pyranochromane skeleton that is 2H,6H-pyrano[3,2-g]chromen-6-one substituted by geminal methyl groups at position 2, a 2,4-dihydroxyphenyl group at position 8, a hydroxy group at position 5 and a prenyl group at position 7. Isolated from Morus alba and Morus species it exhibits anti-inflammatory activity.
Chemical ID: MESH:C542041
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxincreases expressionISOBAX (Homo sapiens)6480464CTDcudraflavone B results in increased expression of BAX proteinPMID:23881456
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTDresveratrol inhibits the reaction [cudraflavone B results in increased expression of BAX protein]; sirtinol promotes the reaction [cudraflavone B results in increased expression of BAX protein]PMID:23881456
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