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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:63933
Term: Aroclor 1254
Definition: A mixture of polychlorobiphenyls of unspecified composition, containing 54% chlorine (X = Cl or H).
Chemical ID: MESH:D020111
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxincreases expressionEXP 6480464CTDChlorodiphenyl (54% Chlorine) results in increased expression of BAX mRNA; Chlorodiphenyl (54% Chlorine) results in increased expression of BAX proteinPMID:23281070
Baxmultiple interactionsEXP 6480464CTDQuercetin inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in increased expression of BAX protein]PMID:23281070
Baxincreases expressionISOBax (Mus musculus)6480464CTDChlorodiphenyl (54% Chlorine) results in increased expression of BAX mRNA; Chlorodiphenyl (54% Chlorine) results in increased expression of BAX proteinPMID:22406624 PMID:25113976
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