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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:4806
Term: (-)-epigallocatechin 3-gallate
Definition: A gallate ester obtained by the formal condensation of gallic acid with the (3R)-hydroxy group of (-)-epigallocatechin.
Chemical ID: MESH:C045651
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxmultiple interactionsEXP 6480464CTD[epigallocatechin gallate co-treated with coenzyme Q10] inhibits the reaction [Cisplatin results in increased expression of BAX protein]; epigallocatechin gallate inhibits the reaction [Acrylamide results in increased expression of BAX mRNA]; epigallocatechin gallate inhibits the reaction [Acrylamide results in increased expression of BAX protein]PMID:27920337 PMID:28056603 PMID:33393703
Baxaffects expressionISOBAX (Homo sapiens)6480464CTDepigallocatechin gallate affects the expression of BAX proteinPMID:15975156
Baxaffects localizationISOBAX (Homo sapiens)6480464CTDepigallocatechin gallate analog affects the localization of BAX proteinPMID:16115949
Baxdecreases expressionISOBAX (Homo sapiens)6480464CTDepigallocatechin gallate results in decreased expression of BAX mRNAPMID:18851785
Baxincreases activityISOBAX (Homo sapiens)6480464CTDepigallocatechin gallate results in increased activity of BAX proteinPMID:15705601
Baxincreases expressionISOBax (Mus musculus)6480464CTDepigallocatechin gallate results in increased expression of BAX proteinPMID:34600025
Baxincreases expressionISOBAX (Homo sapiens)6480464CTDepigallocatechin gallate results in increased expression of BAX proteinPMID:15657356 PMID:15764647 PMID:20149610
Baxincreases response to substanceISOBAX (Homo sapiens)6480464CTDBAX protein results in increased susceptibility to epigallocatechin gallatePMID:15764647
Baxmultiple interactionsISOBax (Mus musculus)6480464CTDepigallocatechin gallate inhibits the reaction [Lipopolysaccharides results in increased expression of BAX protein]; epigallocatechin gallate inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of BAX protein]PMID:36056792 PMID:37286014
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTD[decitabine co-treated with epigallocatechin gallate] affects the expression of BAX mRNA; epigallocatechin gallate inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX protein]; epigallocatechin gallate promotes the reaction [BAX protein binds to BAX protein]PMID:12672908 PMID:15705601 PMID:18250043
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