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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:47898
Term: 4'-epidoxorubicin
Definition: An anthracycline that is the 4'-epi-isomer of doxorubicin.
Chemical ID: MESH:D015251
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxincreases expressionISOBax (Mus musculus)6480464CTDEpirubicin results in increased expression of BAX proteinPMID:26646421 PMID:29505745
Baxincreases expressionISOBAX (Homo sapiens)6480464CTDEpirubicin results in increased expression of BAX mRNAPMID:22914566 PMID:23867903 PMID:26335193
Baxmultiple interactionsISOBax (Mus musculus)6480464CTDpaeonol inhibits the reaction [Epirubicin results in increased expression of BAX protein]PMID:26646421 PMID:29505745
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTD3',4',7-trihydroxyisoflavone promotes the reaction [Epirubicin results in increased expression of BAX mRNA]; [Epirubicin analog co-treated with chrysophsin analog] results in increased expression of BAX mRNA; chrysophsin promotes the reaction [Epirubicin results in increased expression of BAX mRNA]; Epirubicin promotes the reaction [3',4',7-trihydroxyisoflavone results in increased expression of BAX mRNA]; Epirubicin promotes the reaction [chrysophsin results in increased expression of BAX mRNA]; formononetin promotes the reaction [Epirubicin results in increased expression of BAX mRNA]PMID:22914566 PMID:23867903 PMID:26335193
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