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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:46345
Term: 5-fluorouracil
Definition: A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Chemical ID: MESH:D005472
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxincreases expressionEXP 6480464CTDFluorouracil results in increased expression of BAX mRNA; Fluorouracil results in increased expression of BAX proteinPMID:16888818 PMID:38078205
Baxmultiple interactionsEXP 6480464CTDFluorouracil inhibits the reaction [Diethylnitrosamine results in decreased expression of BAX mRNA]PMID:31129132
Baxaffects expressionISOBAX (Homo sapiens)6480464CTDFluorouracil affects the expression of BAX mRNAPMID:23941782
Baxdecreases expressionISOBAX (Homo sapiens)6480464CTDFluorouracil results in decreased expression of BAX proteinPMID:11062132
Baxincreases expressionISOBax (Mus musculus)6480464CTDFluorouracil results in increased expression of BAX proteinPMID:18567086 PMID:19116755 PMID:20844880 PMID:30542770 PMID:32270916
Baxincreases expressionISOBAX (Homo sapiens)6480464CTDFluorouracil results in increased expression of BAX; Fluorouracil results in increased expression of BAX mRNA; Fluorouracil results in increased expression of BAX proteinPMID:11750847 PMID:12442003 PMID:15641988 PMID:15986848 PMID:17045692 PMID:17056233 PMID:17589894 PMID:19116755 PMID:22525470 PMID:25824412 PMID:28599477 PMID:29054700 PMID:31587439 PMID:9388485 PMID:9792140
Baxincreases response to substanceISOBAX (Homo sapiens)6480464CTDBAX protein results in increased susceptibility to FluorouracilPMID:11062132 PMID:16686938
Baxmultiple interactionsISOBax (Mus musculus)6480464CTD[Fluorouracil co-treated with Chitosan co-treated with polyaspartate] results in increased expression of BAX protein; casticin inhibits the reaction [Fluorouracil results in increased expression of BAX protein]; IL1RN protein affects the reaction [Fluorouracil results in increased expression of BAX protein]PMID:18567086 PMID:20844880 PMID:32270916
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTD[[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Fluorouracil] which results in decreased expression of BAX mRNA; [[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Fluorouracil] which results in decreased expression of BAX protein; [Docosahexaenoic Acids co-treated with Fluorouracil] results in increased expression of BAX mRNA; [Fluorouracil co-treated with gamma-Tocopherol] results in increased expression of BAX mRNA; [Fluorouracil co-treated with Irinotecan co-treated with Vorinostat] results in increased expression of BAX protein; [SM-1 compound co-treated with Fluorouracil] results in increased expression of BAX protein; [wogonin co-treated with Fluorouracil] results in increased expression of BAX protein; Aspirin promotes the reaction [Fluorouracil results in increased expression of BAX protein]; Cadmium Chloride affects the reaction [Fluorouracil affects the expression of BAX mRNA]; Fluorouracil affects the reaction [Cadmium Chloride affects the expression of BAX mRNA]; Fluorouracil affects the reaction [rebamipide results in decreased expression of BAX protein]; Fluorouracil promotes the reaction [[Doxorubicin co-treated with Paclitaxel] results in increased expression of BAX protein]; Fluorouracil promotes the reaction [andrographolide affects the folding of BAX protein]; Fluorouracil promotes the reaction [Aspirin results in increased expression of BAX protein]; Fluorouracil promotes the reaction [Plant Extracts results in increased expression of BAX protein]; IFNA1 protein promotes the reaction [Fluorouracil results in increased expression of BAX mRNA]; rebamipide inhibits the reaction [Fluorouracil results in increased expression of BAX protein]; SM-1 compound promotes the reaction [Fluorouracil results in increased expression of BAX mRNA]PMID:15754201 PMID:15986848 PMID:16168113 PMID:17045692 PMID:18834353 PMID:19015929 PMID:19097688 PMID:20570612 PMID:23941782 PMID:28599477 PMID:29054700 PMID:31587439 PMID:32800223
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