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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:44185
Term: methotrexate
Definition: A pteridine that has formula C20H22N8O5.
Chemical ID: MESH:D008727
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxincreases expressionEXP 6480464CTDMethotrexate results in increased expression of BAX mRNA; Methotrexate results in increased expression of BAX proteinPMID:18803016 PMID:28414158 PMID:28479099 PMID:29027214 PMID:31362085 PMID:33720507 PMID:37312617
Baxmultiple interactionsEXP 6480464CTD18alpha-glycyrrhetinic acid inhibits the reaction [Methotrexate results in increased expression of BAX protein]; [Aspartame co-treated with Methotrexate] results in increased expression of BAX mRNA; [Aspartame co-treated with Methotrexate] results in increased expression of BAX protein; Carnitine inhibits the reaction [Methotrexate results in increased expression of BAX protein]; Chlorogenic Acid inhibits the reaction [Methotrexate results in increased expression of BAX protein]; Liraglutide inhibits the reaction [Methotrexate results in increased expression of BAX protein]; Methotrexate inhibits the reaction [Freund's Adjuvant results in increased expression of BAX protein]; sinapinic acid inhibits the reaction [Methotrexate results in increased expression of BAX protein]; TGFA protein inhibits the reaction [Methotrexate results in increased expression of BAX mRNA]; TGFA protein inhibits the reaction [Methotrexate results in increased expression of BAX protein]PMID:18803016 PMID:25009784 PMID:28414158 PMID:28479099 PMID:30025850 PMID:31362085 PMID:33720507 PMID:37312617
Baxaffects expressionISOBAX (Homo sapiens)6480464CTDMethotrexate affects the expression of BAX mRNAPMID:23792648 PMID:25330300
Baxincreases expressionISOBax (Mus musculus)6480464CTDMethotrexate results in increased expression of BAX mRNAPMID:23836430
Baxincreases expressionISOBAX (Homo sapiens)6480464CTDMethotrexate results in increased expression of BAX mRNAPMID:21678067 PMID:29027214
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTDSOD2 protein polymorphism affects the reaction [Methotrexate affects the expression of BAX mRNA]PMID:25330300
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