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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:41879
Term: dexamethasone
Definition: A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID: MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxincreases expressionEXP 6480464CTDDexamethasone results in increased expression of BAX mRNA; Dexamethasone results in increased expression of BAX proteinPMID:19080409 PMID:29111458 PMID:30506661
Baxmultiple interactionsEXP 6480464CTDDexamethasone inhibits the reaction [TGFB1 protein results in increased expression of BAX protein]; fludarabine inhibits the reaction [Dexamethasone results in increased expression of BAX protein]PMID:30506661 PMID:9790906
Baxincreases expressionISOBax (Mus musculus)6480464CTDDexamethasone results in increased expression of BAX mRNA; Dexamethasone results in increased expression of BAX proteinPMID:23935943 PMID:30878453
Baxmultiple interactionsISOBax (Mus musculus)6480464CTD[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with [Dexamethasone co-treated with INS protein co-treated with PRL protein]] results in decreased expression of BAX protein; Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of BAX protein]; Dexamethasone inhibits the reaction [Puromycin Aminonucleoside results in increased expression of BAX protein]; naringin inhibits the reaction [Dexamethasone results in increased expression of BAX protein]PMID:11751460 PMID:15987750 PMID:30878453 PMID:32687258
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTD[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of BAX mRNA; [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of BAX mRNA; [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of BAX mRNAPMID:28628672
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