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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:4031
Term: cyclosporin A
Definition: A cyclic nonribosomal peptide of eleven amino acids; an immunosuppressant drug widely used in post-allogeneic organ transplant to reduce the activity of the patient's immune system, and therefore the risk of organ rejection. Also causes reversible inhibition of immunocompetent lymphocytes in the G0- and G1-phase of the cell cycle.
Chemical ID: MESH:D016572
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxincreases expressionEXP 6480464CTDCyclosporine results in increased expression of BAX; Cyclosporine results in increased expression of BAX mRNA; Cyclosporine results in increased expression of BAX proteinPMID:25299210 PMID:32569592 PMID:33710703
Baxmultiple interactionsEXP 6480464CTDCyclosporine inhibits the reaction [cypermethrin affects the localization of BAX protein]; nilotinib inhibits the reaction [Cyclosporine results in increased expression of BAX mRNA]; nilotinib inhibits the reaction [Cyclosporine results in increased expression of BAX protein]PMID:25370934 PMID:33710703
Baxdecreases expressionISOBAX (Homo sapiens)6480464CTDCyclosporine results in decreased expression of BAX mRNAPMID:25562108
Baxincreases expressionISOBAX (Homo sapiens)6480464CTDCyclosporine results in increased expression of BAX mRNA; Cyclosporine results in increased expression of BAX proteinPMID:20106945 PMID:25596134 PMID:35033536
Baxmultiple interactionsISOBax (Mus musculus)6480464CTDCyclosporine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of BAX protein]; Cyclosporine inhibits the reaction [ginsenoside Re inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased expression of BAX protein]]; Cyclosporine inhibits the reaction [notoginsenoside R1 inhibits the reaction [triethylene glycol dimethacrylate results in increased expression of BAX protein]]; Cyclosporine inhibits the reaction [Reactive Oxygen Species results in increased expression of BAX protein]PMID:10205001 PMID:26884717 PMID:33689844 PMID:37308051
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTDCyclosporine inhibits the reaction [Reactive Oxygen Species results in increased expression of BAX protein]PMID:26884717
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